search.googleThese tails are topic to a number of publish-translational covalent modifications, together with acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ). The exception to the rule is the DOT1 household, members of which methylate K79 in the globular region of histone H3 and which are structurally not associated to SET-area proteins four - 6 Current work means that SET-domain-containing proteins methylate just a few proteins along with histones (see later)